PT  - JOURNAL ARTICLE
AU  - A Pathak
AU  - P Roth
AU  - J Piscitelli
AU  - L Johnson
TI  - Effects of vitamin E supplementation during erythropoietin treatment of the anaemia of prematurity
AID  - 10.1136/fn.88.4.F324
DP  - 2003 Jul 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - F324--F328
VI  - 88
IP  - 4
4099  - http://fn.bmj.com/content/88/4/F324.short
4100  - http://fn.bmj.com/content/88/4/F324.full
SO  - Arch Dis Child Fetal Neonatal Ed2003 Jul 01; 88
AB  - Aims: To evaluate the effects of vitamin E supplementation on haemoglobin concentration and the requirement for transfusion in premature infants treated with erythropoietin and iron. Methods: Randomised, double blind, placebo controlled trial. Thirty infants ≤32 weeks gestation and ≤1250 g birth weight, who were defined as stable based on minimal requirements for respiratory support and phlebotomy, and absence of major congenital anomalies were enrolled. All were treated with erythropoietin and iron, and were randomised to receive, in addition, either vitamin E 50 IU/day or placebo for eight weeks or until discharge, whichever came first. Results: Despite higher vitamin E (α-tocopherol) levels in the experimental group in weeks 3 (49.0 v 28.1 μmol/l) and 8 (66.2 v 38.5 μmol/l), there were no differences in haemoglobin, reticulocyte count, iron concentration, or transfusion requirement. Conclusions: Oral vitamin E supplementation at 50 IU/day does not increase the response of preterm infants to erythropoietin and iron. Vitamin E obtained through standard nutrition may have been sufficient or higher doses may be required.