RT Journal Article
SR Electronic
T1 Nasal high frequency ventilation in neonates with moderate respiratory insufficiency
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F61
OP F63
DO 10.1136/fn.79.1.F61
VO 79
IS 1
A1 Mark van der Hoeven
A1 Erik Brouwer
A1 Carlos E Blanco
YR 1998
UL http://fn.bmj.com/content/79/1/F61.abstract
AB AIM To investigate the efficacy of nasal high frequency ventilation (nHFV) in newborn infants with moderate respiratory insufficiency. METHOD Twenty one preterm and term neonates were treated with nHFV for respiratory insufficiency. Criteria for starting nHFV were: deterioration on nasal CPAP expressed by a median pH of 7.24 and pCO2 of 8.3 kPa, or increasing FIO2. nHFV was delivered using the Infant Star ventilator. Ventilator setting amplitude was 35 cm H2O; mean airway pressure 7 cm H2O; and frequency 10 Hz. RESULTS pCO2decreased significantly from 8.3 kPa to 7.2 kPa after nHFV was started. In five patients nHFV was discontinued after a median period of 6½ hours due to CO2 retention and high oxygen need, and endotracheal mechanical ventilation was started. CONCLUSIONS nHFV can reduce pCO2 in neonates with moderate respiratory insufficiency and, therefore, could be used to decrease the need for endotracheal mechanical ventilation.