TY - JOUR T1 - Markers of collagen metabolism and insulin-like growth factor binding protein-1 in term infants JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F17 LP - F20 DO - 10.1136/fn.83.1.F17 VL - 83 IS - 1 AU - T Hytinantti AU - E-M Rutanen AU - M Turpeinen AU - R Sorva AU - S Andersson Y1 - 2000/07/01 UR - http://fn.bmj.com/content/83/1/F17.abstract N2 - AIM To study the relation between fetal growth and markers of collagen metabolism and insulin-like growth factor binding protein-1 (IGFBP-1) in term infants.METHODS Cord vein plasma was obtained from 67 term infants of gestational age 37.1–41.7 weeks (39 appropriate for gestational age (AGA), 11 large for gestational age (LGA; relative birth weight ⩾ 2.0 SD), and 17 small for gestational age (SGA; relative birth weight ⩽ −2.0 SD)) for analysis of markers of metabolism of collagen type I (PICP and ICTP) and III (PIIINP) and of IGFBP-1.RESULTS Negative correlations existed between gestational age and PICP (r = −0.294, p = 0.0158), ICTP (r = −0.338, p = 0.0052), and PIIINP (r = −0.432, p = 0.0003). These correlations were also found in SGA infants (all p < 0.05). IGFBP-1 showed negative correlations with birth weight and relative birth weight (r = −0.644, p = 0.0001, andr = −0.693, p = 0.0001 respectively) but not with gestational age (p>0.05).CONCLUSIONS In the term fetus, collagen metabolism is primarily dependent on maturity and not on intrauterine growth status, whereas IGFBP-1 reflects intrauterine growth independently of maturity. ER -