@article {GouyonF126, author = {J B Gouyon and B Geneste and D S Semama and M Fran{\c c}oise and J F Germain}, title = {Intravenous nicardipine in hypertensive preterm infants}, volume = {76}, number = {2}, pages = {F126--F127}, year = {1997}, doi = {10.1136/fn.76.2.F126}, publisher = {BMJ Publishing Group}, abstract = {Eight preterm infants were given intravenous nicardipine, a calcium channel blocker, to treat systemic hypertension (renal artery thrombosis (n=3); dexamethasone for management of bronchopulmonary dysplasia (n=2); unexplained (n=3)). Nicardipine doses ranged from 0.5 to 2.0 μg/kg/min and were given for three to 36 days (mean (SD) 15.9 (10.3) days). Systolic blood pressure had significantly decreased after 12 and 24 hours of nicardipine treatment (-17 (17)\% and -21 (10) \%, respectively). Diastolic blood pressure significantly decreased after 24 hours of treatment (-22 {\textpm} 16\%). The decrease in blood pressure remained significant over the subsequent days of treatment. No hypotension or other clinical side effects were observed. It is concluded that intravenous nicardipine could be a first line treatment for hypertension in preterm infants.}, issn = {1359-2998}, URL = {https://fn.bmj.com/content/76/2/F126}, eprint = {https://fn.bmj.com/content/76/2/F126.full.pdf}, journal = {Archives of Disease in Childhood - Fetal and Neonatal Edition} }