TY - JOUR T1 - Antibody response to accelerated Hib immunisation in preterm infants receiving dexamethasone for chronic lung disease JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F69 LP - F71 DO - 10.1136/fn.80.1.F69 VL - 80 IS - 1 AU - M J Robinson AU - F Campbell AU - P Powell AU - D Sims AU - C Thornton Y1 - 1999/01/01 UR - http://fn.bmj.com/content/80/1/F69.abstract N2 - AIM To study the effect of dexamethasone on the routine immunisation of preterm infants with chronic lung disease. METHODS Serum samples were obtained before and after immunisation from an unselected cohort of 59 preterm infants.Haemophilus influenzae antibodies were measured using an ELISA method and differences in the geometric mean values between the two groups of babies analysed. RESULTS Sixteen infants received no dexamethasone. Before and after immunisation antibody titres for those receiving no dexamethasone were 0.16 and 4.63 mcg IgG/ml. Corresponding values for those receiving dexamethasone were 0.10 and 0.51 mcg IgG/ml, respectively. CONCLUSION Dexamethasone used in the treatment of chronic lung disease seems to significantly affect the antibody response of preterm infants to immunisation againstHaemophilus influenzae. ER -