TY - JOUR T1 - Acquired subglottic stenosis caused by methicillin resistant<em>Staphylococcus aureus</em> that produce epidermal cell differentiation inhibitor JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F38 LP - F39 DO - 10.1136/fn.84.1.F38 VL - 84 IS - 1 AU - Y Yamada AU - M Sugai AU - M Woo AU - N Nishida AU - T Sugimoto Y1 - 2001/01/01 UR - http://fn.bmj.com/content/84/1/F38.abstract N2 - Local infection of the trachea in intubated neonates is one of the main risk factors for development of acquired subglottic stenosis, although its role in the pathogenesis is unclear. Methicillin resistantStaphylococcus aureus (MRSA) is often the cause of critical illness in neonatal patients. Two cases are reported of acquired subglottic stenosis following bacterial infection of the trachea, suggesting an association with the staphylococcal exotoxin, epidermal cell differentiation inhibitor (EDIN). EDIN-producing MRSA were isolated from purulent tracheal secretions from both infants. Acquired subglottic stenosis in both cases was probably caused by delayed wound healing as the result of EDIN inhibition of epithelial cell migration. ER -