RT Journal Article SR Electronic T1 Acquired subglottic stenosis caused by methicillin resistantStaphylococcus aureus that produce epidermal cell differentiation inhibitor JF Archives of Disease in Childhood - Fetal and Neonatal Edition JO Arch Dis Child Fetal Neonatal Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP F38 OP F39 DO 10.1136/fn.84.1.F38 VO 84 IS 1 A1 Y Yamada A1 M Sugai A1 M Woo A1 N Nishida A1 T Sugimoto YR 2001 UL http://fn.bmj.com/content/84/1/F38.abstract AB Local infection of the trachea in intubated neonates is one of the main risk factors for development of acquired subglottic stenosis, although its role in the pathogenesis is unclear. Methicillin resistantStaphylococcus aureus (MRSA) is often the cause of critical illness in neonatal patients. Two cases are reported of acquired subglottic stenosis following bacterial infection of the trachea, suggesting an association with the staphylococcal exotoxin, epidermal cell differentiation inhibitor (EDIN). EDIN-producing MRSA were isolated from purulent tracheal secretions from both infants. Acquired subglottic stenosis in both cases was probably caused by delayed wound healing as the result of EDIN inhibition of epithelial cell migration.