TY - JOUR T1 - Cerebral blood flow during treatment for pulmonary hypertension JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F30 LP - F33 DO - 10.1136/fn.80.1.F30 VL - 80 IS - 1 AU - Satoshi Kusuda AU - Norio Shishida AU - Nobuhiro Miyagi AU - Madoka Hirabayashi AU - Tae-Jang Kim Y1 - 1999/01/01 UR - http://fn.bmj.com/content/80/1/F30.abstract N2 - AIM To determine if the haemodynamics of systemic and cerebral circulation are changed during treatment for persistent pulmonary hypertension of the newborn (PPHN). METHODS Fifteen term newborn piglets with hypoxia induced pulmonary hypertension were randomly assigned either tolazoline infusion (Tz), hyperventilation alkalosis (HAT), and inhaled nitric oxide (iNO). Mean pulmonary arterial pressure (PAP), mean systemic arterial pressure (SAP), and cerebral blood flow volume (CBF) were measured. RESULTS During hypoxic breathing, PAP increased significantly in all groups. After treatment PAP decreased significantly in all groups, but no significant difference was observed between groups. SAP decreased significantly only in the Tz group, and CBF reduced significantly only in the HAT group. On the other hand, iNO did not change SAP or CBF. CONCLUSION Inhaled NO might be ideal for the resolution of pulmonary hypertension. ER -