RT Journal Article
SR Electronic
T1 Thyroid function in very low birthweight infants after intravenous administration of the iodinated contrast medium iopromide
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F215
OP F217
DO 10.1136/fn.82.3.F215
VO 82
IS 3
A1 J Dembinski
A1 V Arpe
A1 M Kroll
A1 G Hieronimi
A1 P Bartmann
YR 2000
UL http://fn.bmj.com/content/82/3/F215.abstract
AB BACKGROUND Thyroid function disorders have often been observed in preterm infants after intravenous administration of iodinated contrast medium. The effect on thyroid function depends on the dosage, but the choice of the contrast medium may be equally important, as there are appreciable pharmacological differences between them.METHOD Thyroid function was analysed in 20 very low birthweight infants of gestational age less than 30 weeks after injection of iopromide, a monomeric non-ionic iodinated contrast medium. Levels of free thyroxine and thyroid stimulating hormone were compared with those in 26 control infants.RESULTS Free thyroxine levels in all study infants ranged from 9.0 to 25.7 pmol/l (days 14–21) and 9.0 to 23.2 pmol/l (days 35–49), and thyroid stimulating hormone levels ranged from 0.13 to 0.26 mU/l (days 14–21) and 0.26 to 11.11 mU/l (days 35–49). These levels were not altered after injection of iopromide.CONCLUSION The risk of transient hypothyroidism or hyperthyrotropinaemia may be reduced with the use of iopromide compared with other contrast media.