RT Journal Article
SR Electronic
T1 Observational study of maternal anthropometry and fetal insulin
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F122
OP F124
DO 10.1136/fn.81.2.F122
VO 81
IS 2
A1 H Soltani-K
A1 C Bruce
A1 R B Fraser
YR 1999
UL http://fn.bmj.com/content/81/2/F122.abstract
AB AIMS To examine the relation between maternal body fat and fetal metabolism. METHODS In this observational study, cord blood samples were collected from 60 infants of healthy women for the measurement of insulin and C peptide concentrations. Maternal weight, height, body mass index (BMI) and body composition (skinfold thickness measurements and bioelectrical impedance) were assessed at 13–15 weeks of gestation. Twenty five of the volunteers agreed to have a 75 g oral glucose tolerance test at 28–31 weeks of gestation. RESULTS Positive correlations were observed with both cord insulin or C peptide concentrations and maternal early pregnancy BMI (r=0.44, p=0.002 and r=0.33, p=0.008, respectively). There was no significant correlation between cord insulin or C peptide concentrations and birthweight or birth weight centiles. CONCLUSION Maternal BMI could be a predictor of fetal cord insulin concentration.