TY - JOUR T1 - Basal ganglia damage and impaired visual function in the newborn infant JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F111 LP - F114 DO - 10.1136/fn.77.2.F111 VL - 77 IS - 2 AU - Eugenio Mercuri AU - Janette Atkinson AU - Oliver Braddick AU - Shirley Anker AU - Frances Cowan AU - Mary Rutherford AU - Jackie Pennock AU - Lilly Dubowitz Y1 - 1997/09/01 UR - http://fn.bmj.com/content/77/2/F111.abstract N2 - AIM To examine the effects of early lesions in the visual pathway on visual function; and to identify early prognostic indicators of visual abnormalities. METHODS The visual function of 37 infants with perinatal brain lesions on magnetic resonance imaging was assessed using behavioural and electrophysiological variables. RESULTS Normal visual behaviour was observed in most infants with large bilateral occipital lesions, but all the infants with associated basal ganglia involvement had abnormal visual function. Visual abnormalities were also present in six infants with isolated basal ganglia lesions. CONCLUSIONS These observations suggest that basal ganglia may have an integral role in human visual development and that their presence on neonatal MRI could be an early marker of abnormal visual function. Key messages • In agreement with previous animal studies, our study has suggested that basal ganglia may play an important role in infant’s vision. • The involvement of basal ganglia on neonatal MRI, seems to be more often associated with impaired visual function than lesions involving the visual occipital cortex. • A wide battery of tests is necessary to evaluate various aspects of visual function. ER -