PT  - JOURNAL ARTICLE
AU  - A Aynsley-Green
AU  - K Hussain
AU  - J Hall
AU  - J M Saudubray
AU  - C Nihoul-Fékété
AU  - P De Lonlay-Debeney
AU  - F Brunelle
AU  - T Otonkoski
AU  - P Thornton
AU  - K J Lindley
TI  - Practical management of hyperinsulinism in infancy
AID  - 10.1136/fn.82.2.F98
DP  - 2000 Mar 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - F98--F107
VI  - 82
IP  - 2
4099  - http://fn.bmj.com/content/82/2/F98.short
4100  - http://fn.bmj.com/content/82/2/F98.full
SO  - Arch Dis Child Fetal Neonatal Ed2000 Mar 01; 82
AB  - Hyperinsulinism in infancy is one of the most difficult problems to manage in contemporary paediatric endocrinology. Although the diagnosis can usually be achieved without difficulty, it presents the paediatrician with formidable day to day management problems. Despite recent advances in understanding the pathophysiology of hyperinsulinism, the neurological outcome remains poor, and there is often a choice of unsatisfactory treatments, with life long sequelae for the child and his or her family. This paper presents a state of the art overview on management derived from a consensus workshop held by the European network for research into hyperinsulinism (ENRHI). The consensus is presented as an educational aid for paediatricians and children's nurses. It offers a practical guide to management based on the most up to date knowledge. It presents a proposed management cascade and focuses on the clinical recognition of the disease, the immediate steps that should be taken to stabilise the infant during diagnostic investigations, and the principles of definitive treatment.