RT Journal Article
SR Electronic
T1 Measurement of interleukin 10 in bronchoalveolar lavage from preterm ventilated infants
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F156
OP F159
DO 10.1136/fn.82.2.F156
VO 82
IS 2
A1 McColm, Janet R
A1 Stenson, Ben J
A1 Biermasz, Nienke
A1 McIntosh, Neil
YR 2000
UL http://fn.bmj.com/content/82/2/F156.abstract
AB BACKGROUND Interleukin 10 (IL-10) is a cytokine that downregulates inflammation, in part by reducing the production of the proinflammatory cytokines IL-1β and IL-8. It has been suggested that an inability to produce IL-10 might predispose preterm infants to develop chronic lung disease.AIM To measure IL-10, IL-1β, and IL-8 in bronchoalveolar lavage fluid from ventilated preterm infants in a prospective cohort study.PATIENTS 17 consecutive newborn infants ⩽ 29 weeks' gestational age (median, 25; 9 boys) who were ventilated from birth underwent daily bronchoalveolar lavage sampling.RESULTS 102 samples were collected, of which 57 contained IL-10 in amounts that were comparable with those found previously in ventilated term infants with respiratory failure. Chronic lung disease developed in 9 of the 11 survivors and all 9 infants had produced IL-10. IL-1β and IL-8 were detected in nearly all samples and were raised throughout the course of sample collection.CONCLUSION IL-10 is readily detectable in early bronchoalveolar lavage samples from ventilated preterm infants, although it remains unclear whether this cytokine has any influence on the development of chronic lung disease.