PT  - JOURNAL ARTICLE
AU  - Janet R McColm
AU  - Ben J Stenson
AU  - Nienke Biermasz
AU  - Neil McIntosh
TI  - Measurement of interleukin 10 in bronchoalveolar lavage from preterm ventilated infants
AID  - 10.1136/fn.82.2.F156
DP  - 2000 Mar 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - F156--F159
VI  - 82
IP  - 2
4099  - http://fn.bmj.com/content/82/2/F156.short
4100  - http://fn.bmj.com/content/82/2/F156.full
SO  - Arch Dis Child Fetal Neonatal Ed2000 Mar 01; 82
AB  - BACKGROUND Interleukin 10 (IL-10) is a cytokine that downregulates inflammation, in part by reducing the production of the proinflammatory cytokines IL-1β and IL-8. It has been suggested that an inability to produce IL-10 might predispose preterm infants to develop chronic lung disease.AIM To measure IL-10, IL-1β, and IL-8 in bronchoalveolar lavage fluid from ventilated preterm infants in a prospective cohort study.PATIENTS 17 consecutive newborn infants ⩽ 29 weeks' gestational age (median, 25; 9 boys) who were ventilated from birth underwent daily bronchoalveolar lavage sampling.RESULTS 102 samples were collected, of which 57 contained IL-10 in amounts that were comparable with those found previously in ventilated term infants with respiratory failure. Chronic lung disease developed in 9 of the 11 survivors and all 9 infants had produced IL-10. IL-1β and IL-8 were detected in nearly all samples and were raised throughout the course of sample collection.CONCLUSION IL-10 is readily detectable in early bronchoalveolar lavage samples from ventilated preterm infants, although it remains unclear whether this cytokine has any influence on the development of chronic lung disease.