PT - JOURNAL ARTICLE AU - O. Pryds AU - A. D. Edwards TI - Cerebral blood flow in the newborn infant. AID - 10.1136/fn.74.1.F63 DP - 1996 Jan 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - F63--F69 VI - 74 IP - 1 4099 - http://fn.bmj.com/content/74/1/F63.short 4100 - http://fn.bmj.com/content/74/1/F63.full SO - Arch Dis Child Fetal Neonatal Ed1996 Jan 01; 74 AB - Studies of CBF have provided some insight into cerebrovascular physiology and pharmacology. However, the precise relation between CBF and cerebral damage remains elusive, and there is no definition of a threshold CBF below which ischaemic brain damage always occurs. Measurement of CBF thus does not currently provide a secure guide in the clinical management of sick infants. Further work, particularly using techniques like magnetic resonance imaging and NIRS, which provide data in addition to CBF measurements, may yet disclose strategies which manipulate CBF to reduce cerebral ischaemia. While cerebral injury remains a substantial problem in neonatal intensive care, such research is urgently needed.