PT  - JOURNAL ARTICLE
AU  - Levene, M.
AU  - Blennow, M.
AU  - Whitelaw, A.
AU  - Hankø, E.
AU  - Fellman, V.
AU  - Hartley, R.
TI  - Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia.
AID  - 10.1136/fn.73.3.F174
DP  - 1995 Nov 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - F174--F177
VI  - 73
IP  - 3
4099  - http://fn.bmj.com/content/73/3/F174.short
4100  - http://fn.bmj.com/content/73/3/F174.full
SO  - Arch Dis Child Fetal Neonatal Ed1995 Nov 01; 73
AB  - The effects of two different doses of magnesium sulphate (MgSO4) were evaluated in a group of 15 full term infants with Apgar scores of < 6 at 10 minutes, studied within 12 hours of delivery. Seven infants received 400 mg/kg MgSO4 and eight received 250 mg/kg. After the larger dose, mean arterial pressure (MAP) fell by a mean of 6 mm Hg (13%) at one hour but was not significantly reduced thereafter. Respiratory depression lasted three to six hours. EEG readings and heart rate were not significantly different. Mean serum Mg2+ increased from 0.79 to 3.6 mmol/l at one hour. After 250 mg/kg MgSO4, MAP, EEG, tone and heart rate were unchanged. One infant developed transient respiratory depression. Mean serum Mg2+ rose from 0.71 to 2.42 mmol/l at one hour. MgSO4 (400 mg/kg) has an unacceptable risk of hypotension; 250 mg/kg MgSO4 was not associated with hypotension although respiratory depression can occur.