238 e-Letters

published between 2001 and 2004

  • Lipopolysaccharide binding protein in preterm infants
    Sudhin Thayyil

    Dear Editor,

    Congratulations to Behrendt and team for introducing yet another infection marker in premature babies [1]. However, there are several flaws in the study design which could render the study conclusions not clinically useful.

    The authors repeatedly mention the aim of their study was to look at lipopolysaccharide binding protein (LBP) levels in premature babies. Results quoted however includ...

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  • Loss of antioxidants in breastmilk: what is the clinical relevance?
    Alicia R Dermer, MD

    Dear Editor,

    The study on storage of breastmilk and its effect on antioxidant levels [1] was well designed and provided some interesting information. However, the conclusions that the authors drew are based on conjecture about the clinical relevance of the findings. There is a potential risk to infant health if mothers follow their recommendations and abandon the pumping and storage of their milk.

    The authors...

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  • Yes, human milk does reduce infection rates in VLBW infants
    Lydia Furman

    Dear Editor,

    Drs. De Silva, Jones and Spencer have provided a timely review of issues relating to studies of breastmilk feeding for VLBW infants and rates of infection [1]. We would appreciate the opportunity to clarify some points they have raised regarding our study [2]. We believe our results clearly support our conclusion: that intake of greater than 50 ml/kg/day of maternal milk through week four of life...

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  • Reply to : Septic infants: Pandora box reopens
    Dror Mandel

    Dear Editor

    We appreciate the interest of Dr Gupta and his thoughtful comments.[1]

    1. Primary disease of the neonates included in the study: Our original submission to the journal included a complete table describing in many more details the patient population. At the request of the reviewers/editors to shorten the paper, we removed the table which is now attached at the end of this letter.

    2. Antibiot...

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  • Inadvertent overdosing of neonates due to dead space of syringe hub and needle
    Vikas Bhambhani

    Dear Editor,

    Chappell and Newman [1] have asked for urgent initiatives needed to ensure the manufacture of neonatal targeted products to reduce the risks associated with intravenous drug administration. We endorse their view and report a little recognized problem with use of adult formulations in neonatal nurseries

    This investigation was conducted after we noticed symptoms of Digoxin overdose (brady-arrhythmia)...

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  • Neonatal coagulopathy: is the liver OK?
    Nedim Hadzic

    Dear Editor,

    I have read with interest a systematic and well-referenced review of causes of neonatal coagulation disorders in recent Archives [1]. However, amongst non-haematological causes of the coagulopathies the author has failed to mention a small, but significant subgroup of patients with neonatal liver failure (NLF).

    This condition could often be difficult to diagnose due to presence of jaundice (ea...

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  • Recording of central venous line tips post insertion
    Edna NK Asumang

    Dear Editor,

    I read with interest the publication of the audit on the use of central venous lines(CVL) by DW Cartwright.

    He reported that 58.6% of the catheters were postioned in the right atrium, but there was no breakdown of where the other 41.8% tips were located. Probably this was because he was interested in only catheters in the right atrium. I would have liked to know as well if this information was i...

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  • Response to Prof. Shah's Letter
    George M. Morley

    Dear Editor,

    Professor Shah has submitted a comprehensive and well-documented response that agrees and disagrees with my letters. With clarification of a few points, I find that we may be very close to complete agreement, and to major improvement in neonatal outcome.

    Regarding the definition of “asphyxia,” for want of a better, I use the term to describe the sum total of pathologies produced by compressi...

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  • Less invasive autopsy : many questions remain
    Andrew C Breeze

    Dear Editor,

    Wright and Lee's article [1] provides an excellent overview of the options to consider when parents decline the offer of conventional autopsy following perinatal death.

    Although a less invasive autopsy (LIA), such as one based on MRI, may be more acceptable to many parents, the provision of such a service could have significant implications, not just with regard to the availability of a scar...

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  • Interpreting immunisation data requires complete information
    Janet E Berrington

    Dear Editor,

    The primary immunisation schedule in the UK is about to change for the seventh time since the accelerated schedule was introduced in 1990. The latest change, to a combined DTPaHibIPV vaccine (Pediacel), provoked a flurry of lay concern.

    Given the rapid advancement of vaccine technology that has prompted such frequent changes to our primary immunisation policy it is inevitable that we would...

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