Response: Chorioamnionitis, lung function and bronchopulmonary dysplasia in prematurely born infants
NeilEverest, Neonatal Fellow,
March 22, 2016
Dear Sir,
The article by Prendergast et al describes an important outcome following
a very common antenatal complication. However, there is no description of
the proportion of infants surviving in the two groups which may overshadow
any lack of difference in BPD development between the two groups.
In the statistical methods no assessment appears to have been made in the
regression model between duration of membrane rupture and BPD risk. An
interaction could also have also been tested within the regression model
to assess whether any effect modification exists between duration of
membrane rupture and presence of chorioamnionitis.
This additional information would be of use for counselling parents
following delivery in the presence of chorioamnionitis.
Dear Sir,
The article by Prendergast et al describes an important outcome following a very common antenatal complication. However, there is no description of the proportion of infants surviving in the two groups which may overshadow any lack of difference in BPD development between the two groups. In the statistical methods no assessment appears to have been made in the regression model between duration of membrane rupture and BPD risk. An interaction could also have also been tested within the regression model to assess whether any effect modification exists between duration of membrane rupture and presence of chorioamnionitis. This additional information would be of use for counselling parents following delivery in the presence of chorioamnionitis.
Yours Sincerely Dr Neil Everest
Conflict of Interest:
None declared