Online First
August 25, 2021
- Original researchNecrotising enterocolitis, late-onset sepsis and mortality after routine probiotic introduction in the UK
In this single-centre retrospective review of more than 1000 infants born before 32 week's gestation. The routine introduction of multi-strain probiotics was not associated with changes in the risk of mortality or necrotising enterocolitis.
August 23, 2021
- Original researchIdentification of treatment-warranted retinopathy of prematurity by neonatal nurse specialist
This study demonstrates that screening for retinopathy of prematurity treatment can be performed by a specialist nurse practitioner obtaining and interpreting digital retinal images, with excellent agreement with treating ophthalmologists.
August 19, 2021
- Original researchIndividualised decision making: interpretation of risk for extremely preterm infants—a survey of UK neonatal professionals
Topical and important insight into the current state of play in the UK regarding active management at the limit of viability.
- Original researchObservational cohort study of changing trends in non-invasive ventilation in very preterm infants and associations with clinical outcomes
This analysis of the National Neonatal Research Database from 2010-17 shows that the use of high-flow nasal cannula quadrupled, particularly as initial respiratory support, but was associated with adverse outcomes including BPD.
- Original researchVideo-based reflection on neonatal interventions during COVID-19 using eye-tracking glasses: an observational study
Single centre evaluation of the use of eye-tracking glasses during neonatal procedures as an additional tool for outside teaching and video-based reflection. The feasibility and potential benefit during a pandemic is reported.
- Original researchCharacteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study
This two-year prospective nationwide surveillance study of neonatal HSV infections finds few cases in Germany. Most children had few symptoms and good outcomes, but five infants had significant sequelae. Orofacial HSV infection was present in one or more family members for 20/23 babies where data was available, but it is not clear if this was the mode of transmission.
- Short reportTiming of neonatal stoma closure: a survey of health professional perspectives and current practice
This survey reports the perspectives of 166 respondents from 27 UK neonatal surgical centres regarding timing of neonatal stoma closure
August 04, 2021
August 03, 2021
- Original researchMonitoring of carbon dioxide in ventilated neonates: a prospective observational study
This study comparing the precision and accuracy of end-tidal and transcutaneous pCO2 with arterial measurements found that end-tidal CO2, measured through a double-lumen ET tube in ventilated neonates, was superior to tcpCO2.
August 02, 2021
- Original researchComparison of three intraosseous access devices for resuscitation of term neonates: a randomised simulation study
Three different devices for intra-osseous access during were evaluated in a bone model intended to simulate insertion in term newborns. A total of 92 paediatricians were involved. Success rates were markedly different between devices.
July 30, 2021
- Original researchOutcomes of very preterm infants with neonatal hyperglycaemia: a systematic review and meta-analysis
In a systematic review and meta-analysis, hyperglycemia in very preterm infants is associated with higher odds of mortality, IVH, and ROP.
- Original researchAssessment of optimal chest compression depth during neonatal cardiopulmonary resuscitation: a randomised controlled animal trial
In an asphyxiated piglet model, time to return of spontaneous circulation was similar for chest compressions 25%, 33%, and 40% anterior-posterior depth, while Increasing compression depth improved hemodynamic and respiratory parameters.
July 29, 2021
July 28, 2021
- Original researchTemporal trends in respiratory care and bronchopulmonary dysplasia in very preterm infants over a 10-year period in Spain
National survey of changes in respiratory outcomes of VLBW infants over 2 periods, showing that outcome did not improve despite an increase in the use of non-invasive ventilation.
- Original researchOesophageal atresia: sonographic signs may prenatally predict surgical complexity
This manuscript characterizes prenatal ultrasound findings of babies with esophageal atresia with the presence or absence of a distal fistula. The authors found several ultrasound parameters were correlated with more complex repair and absence of a distal fistula
- Original researchDirect swallowing training and oral sensorimotor stimulation in preterm infants: a randomised controlled trial
This single centre, masked RCT enrolling 186 infants <32 weeks gestation found that direct swallowing training combined with oral sensorimotor stimulation significantly shortened the time to independent oral feeding compared with no intervention.
July 19, 2021
- Original researchTemporal trends of in utero and early postnatal transfer of extremely preterm infants between 2011 and 2016: a UK population study
Between 2011 and 2016, the rate of intra-uterine transfer of extremely preterm infants within the UK decreased, with an associated increase in early postnatal transfer. This also includes early postnatal transfer between level 3 NICUs.
July 14, 2021
- Original researchHead circumference, total cerebral volume and neurodevelopment in preterm neonates
This paper looks at the relationship between head growth during neonatal unit stay and neurodevelopmental outcomes in a prospective cohort.
July 13, 2021
- Original researchGrowth in extremely preterm children born in England in 1995 and 2006: the EPICure studies
This paper describes the growth to age 11 of a sample of the EPICure 2 2006 preterm birth cohort, compared to healthy same age controls and to the 1995 EPICure cohort. Since 1995, childhood growth in weight, height and BMI have improved for births <26 weeks of gestation, but there was no improvement in head growth.
- Original researchTitres and neutralising capacity of SARS-CoV-2-specific antibodies in human milk: a systematic review
Systematic review on the titers and neutralising capacity of SARS-CoV-2-specific antibodies in human milk demonstrates that these antibodies can neutralise the virus in vitro. Furthermore, high pressure, but not Holder pasteurisation deactivates the specific IgAs.
July 07, 2021
- Original researchComparison of volume guarantee and volume-controlled ventilation both using closed loop inspired oxygen in preterm infants: a randomised crossover study (CLIO-VG study)
Cross-over study addressing whether improved time within oxygen saturation target can be primarily improved by volume-controlled ventilation or automatic control of the FiO2, with the results clearly showing that the latter is more important for reaching this goal
- Short reportAntenatal magnesium sulfate to prevent cerebral palsy
Embedding a quality improvement program on prenatal magnesium administration is feasible to reduce the impact of cerebral palsy.
June 29, 2021
- Images in neonatal medicineUmbilical cord thrombosis and chorioamnionitis in neonatal arterial ischaemic stroke
June 25, 2021
June 18, 2021
June 15, 2021
June 03, 2021
May 27, 2021
- Images in neonatal medicineCongenital cutaneous candidiasis in one infant among a twin sibling pair
May 10, 2021
- ReviewNeuroscience meets nurture: challenges of prematurity and the critical role of family-centred and developmental care as a key part of the neuroprotection care bundle
This review examines the developmental milestones of fetal brain and how preterm birth can disrupt this trajectory. It then outlines effective non-medical, family-centred and developmental care strategies which have the potential to improve neurodevelopmental outcomes.
May 05, 2021
April 27, 2021
- ReviewRed cell transfusion thresholds for preterm infants: finally some answers
A review of the current evidence for red cell transfusions for preterm infants.
April 21, 2021
- ReviewSafe emergency neonatal airway management: current challenges and potential approaches
This review describes the challenges encountered with neonatal intubation, particularly in relation to training and achieving competency. It discusses strategies to optimise intubation success and examines the airway adjuncts currently available to manage the neonatal airway.
April 13, 2021
- Images in neonatal medicinePericardial effusion and pulmonary vein stenosis in severe bronchopulmonary dysplasia
March 03, 2021
- ReviewCurrent evidence for prenatal and postnatal corticosteroids in preterm infants
The review article looks at the current evidence for steroids in preterm infants, both pre- and postnatally.
February 24, 2021
February 10, 2021
- Images in neonatal medicineEcthyma gangrenosum in a premature infant: rare but critical to recognise
February 04, 2021
- Images in neonatal medicineEarly recognition of rusty pipe syndrome to avoid disruption of breast feeding