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Timing and adequacy of intrapartum antibiotic prophylaxis: new insights for future guidelines
  1. Francesca Miselli1,2,
  2. Licia Lugli2,
  3. Luca Bedetti1,2,
  4. Sofia Mazzotti2,
  5. Martina Buttera2,
  6. Alberto Berardi1,2
  1. 1University of Modena and Reggio Emilia, Modena, Italy
  2. 2University Hospital of Modena, Modena, Italy
  1. Correspondence to Dr Francesca Miselli; misellifrancesca0{at}

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We have read with interest the study by Nielsen et al,1 which adds valuable insights to the ongoing discussion surrounding the timing and dosage of intrapartum antibiotic prophylaxis (IAP) for preventing early-onset group B streptococcal disease (EOD).

The study confirms that transplacental transfer of penicillin is significant: umbilical cord levels of antibiotics are high even for short durations of IAP, and they remain elevated when maternal levels are low. This observation indicates that reassessing current guidelines regarding the timing and adequacy of IAP may be beneficial.

In fact, current guidelines recommend IAP durations of at least …

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.