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Reply to: ‘Statistical power in “Prophylactic surfactant nebulisation for the early aeration of the preterm lung: a randomised clinical trial”’
  1. Vincent D Gaertner1,2,
  2. Dirk Bassler1,
  3. Christoph Martin Rüegger1
  1. 1 Newborn Research Zurich, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland
  2. 2 Division of Neonatology, Dr von Hauner Children's Hospital, Ludwig Maximilians University (LMU) Munich, Munich, Germany
  1. Correspondence to Dr Vincent D Gaertner, Department of Neonatology, University of Zurich, Zurich, Switzerland; vincent.gaertner{at}

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We thank Dr Hagan for his letter highlighting the importance of a critical interpretation of statistical analyses. 1 2 Designing trials to investigate novel therapeutic approaches in the neonatal population is difficult, mainly due to lack of high-quality data for adequate sample size calculation. For this reason, we performed electrical impedance tomography pilot measurements in five healthy very preterm infants immediately after birth to generate baseline data.

As correctly noted by Dr Hagan, the assumption of normality was violated for the primary outcome in our final data set, and thus, a non-parametric test was used for analysis. In addition, the IQR was larger than expected based on our …

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  • Contributors VDG, DB and CMR wrote the reply to the letter.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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