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Gaertner et al1 published a randomised clinical trial of preterm infants comparing, as the primary outcome, the difference in end-expiratory lung impedance from birth to 30 min after birth (ΔEELI30min) for infants randomised to receive positive distending pressure, either alone (standard care) or with surfactant nebulisation (SN). The study sample size of 16 patients per treatment arm was calculated to achieve 80% statistical power to detect a mean difference in treatments’ ΔEELI30min of 11 AU/kg at the 5% significance level. An SD of 11 AU/kg from pilot measurements was used for this sample size calculation. The ΔEELI30min SDs observed in the study were not reported, but …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.