Article Text

Download PDFPDF
What’s New in the Management of Neonatal Early-Onset Sepsis?
  1. Noa Fleiss1,
  2. Kathleen Schwabenbauer2,
  3. Tara M Randis3,
  4. Richard A Polin4
  1. 1Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA
  2. 2Pediatrics, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania, USA
  3. 3Pediatrics, University of South Florida College of Medicine, Tampa, Florida, USA
  4. 4Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
  1. Correspondence to Dr Richard A Polin, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; rap32{at}


The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and standardised approach to antibiotic use. While these guidelines have significantly reduced antibiotic utilisation worldwide, optimally each unit would individualise their approach to early onset sepsis (EOS) based on the neonatal population they serve and available resources. As advancements in EOS research continue and limitations with sepsis prediction tools are addressed, it is inevitable that our risk stratification and management guidelines will become more precise.

  • Infectious Disease Medicine
  • Neonatology

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Twitter @nfleiss

  • Contributors All the authors have contributed to the writing and editing of this manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.