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Characteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study
  1. André Kidszun1,2,
  2. Anna Bruns1,
  3. Daniel Schreiner1,
  4. Susanne Tippmann1,
  5. Julia Winter1,
  6. Roman M Pokora3,
  7. Michael S Urschitz3,
  8. Eva Mildenberger1
  1. 1Division of Neonatology, Department of Paediatrics, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Rheinland-Pfalz, Germany
  2. 2Division of Neonatology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  3. 3Division of Paediatric Epidemiology, Institute of Medical Biostatistics, Epidemiology, and Informatics, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Rheinland-Pfalz, Germany
  1. Correspondence to André Kidszun, Division of Neonatology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Bern, Switzerland; andre.kidszun{at}insel.ch

Abstract

Objective To assess incidence and burden of neonatal herpes simplex virus (HSV) infections and to explore possible transmission routes.

Methods A 2-year prospective nationwide surveillance study performed in 2017 and 2018. All German paediatric departments (n=464 in 2017, n=441 in 2018) were contacted on a monthly basis to report potential cases of neonatal HSV infections. Infants with a postnatal age of ≤60 days and a positive HSV PCR or HSV culture from skin, mucous membrane, vesicles or conjunctival smear, blood or cerebrospinal fluid were included in the study.

Results 37 cases were analysed. 29 patients who exhibited no or only mild clinical symptoms were discharged home without organ damage or neurological abnormalities. Four patients showed significant neurological impairment, one patient required liver transplantation and two patients died during in-patient treatment. The 2-year incidence of neonatal HSV infections was 2.35 per 100 000 live births (95% CI 1.69 to 3.02) and disease-specific mortality was 0.13 per 100 000 live births (95% CI 0.04 to 0.21). Data on possible transmission routes were available in 23 cases. In 20 cases, an orofacial HSV infection was present in one or more family members. An active maternal genital HSV infection was reported in 3 cases.

Conclusion Neonatal HSV infections are rare in Germany. Most infants have a benign clinical course, but some infants are severely affected. Postnatal HSV exposure may account for a considerable number of neonatal HSV infections.

  • epidemiology
  • neonatology
  • virology

Data availability statement

Data are available on reasonable request.

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Data availability statement

Data are available on reasonable request.

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Footnotes

  • Contributors AK: conceived the idea of the study, coordinated and supervised data collection, evaluated the analyses, and drafted the initial and the revised manuscript. AB: participated in data collection, carried out the statistical analyses and critically reviewed the manuscript. DS: evaluated the analyses and critically reviewed the manuscript. ST: supervised data collection, evaluated the analyses and critically reviewed the manuscript. JW: evaluated the analyses and critically reviewed the manuscript. RMP: participated in data collection, supervised the statistical analyses, and critically reviewed and revised the manuscript. MSU: supervised the statistical analyses and critically reviewed the manuscript. EM: conceptualised, designed and supervised the study, and critically reviewed the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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