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Discriminating necrotising enterocolitis and focal intestinal perforation
  1. Janet Berrington1,2,
  2. Nicholas D Embleton1,3
  1. 1Neonatology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK
  2. 2Translational and Clinical Research Institute, Newcastle University, Newcastle, UK
  3. 3Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK
  1. Correspondence to Dr Janet Berrington, Neonatology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK; j.e.berrington{at}ncl.ac.uk

Abstract

Discriminating necrotising enterocolitis (NEC) and focal intestinal perforation (FIP) is important for clinical trials, observational cohorts, quality improvement and aetiological understanding. Literature suggests that timing and key features diagnose and discriminate, and that NEC subclassifications exist. We used a detailed 10-year cohort of NEC and FIP cases in preterm infants born <32 weeks’ gestation from a single centre to explore antecedent factors, presentation and potential NEC subclassifications. 785 infants had 144 episodes of NEC and 38 of FIP. FIP presented earlier than NEC, but ranges overlapped, and 30% of NEC presented before day 14. Antecedent events (other than feed volumes) and outcomes did not differ between NEC and FIP. Currently used diagnostic/discriminatory features performed poorly, and subclassification identified few cases except transfusion-associated NEC. Contrary to existing literature, postnatal age at NEC presentation was not dependent on gestational age. Detailed review rather than simple definitions are required to separate NEC from FIP.

  • gastroenterology
  • epidemiology
  • neonatology

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Data availability statement

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Footnotes

  • Twitter @neonatalbiobank, @NeoResearch_Net

  • Contributors NDE and JB contributed equally.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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