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Nicolau syndrome or ‘embolia cutis medicamentosa’ in a newborn: successful treatment with a surgical intervention
  1. Brena Costa Santos,
  2. Rebeca Mangabeira Correia,
  3. Danielle Akemi Bergara Kuramoto,
  4. Ana Alyra Garcia Carvalho,
  5. Rafael Bernardes Avila,
  6. Jorge Eduardo Amorim,
  7. Ronald Luiz Gomes Flumignan,
  8. Luis Carlos Uta Nakano
  1. Division of Vascular and Endovascular Surgery, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  1. Correspondence to Professor Ronald Luiz Gomes Flumignan, Division of Vascular and Endovascular Surgery, 754 Rua Borges Lagoa, 04038-002, Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil; flumignan{at}gmail.com

https://doi.org/10.1136/archdischild-2021-321637

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    A 3-day-old male newborn was referred to a quaternary hospital with pain, pallor and cyanosis of the left lower limb for the past 2 days of admission. These signs and symptoms started immediately after intramuscular injection of 50 000 IU of benzathine penicillin G at the lateral face of his left thigh to treat possible congenital syphilis. After diagnosis of acute compartment syndrome secondary to Nicolau syndrome (NS) (figure 1A), the assistant team immediately performed a fasciotomy of the left lower limb …

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    Footnotes

    • Twitter @ronaldflumignan

    • Contributors BCS, RLGF and LCUN conceptualised and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. RMC, DABK, AAGC, RBA and JEA designed the data collection instruments, collected the data, carried out the initial analyses, and reviewed and revised the manuscript. LCUN and RLGF conceptualised and designed the study, coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.