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Prematurity and postnatal alterations in intermittent hypoxaemia
  1. Juliann M Di Fiore1,
  2. Vidhi Shah2,
  3. Abhijit Patwardhan3,
  4. Abdus Sattar1,
  5. Shengxuan Wang1,
  6. Thomas Raffay1,
  7. Richard J Martin4,
  8. Elie G Abu Jawdeh5
  1. 1 Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
  2. 2 Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
  3. 3 Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA
  4. 4 Department of Pediatrics, Rainbow Babies Childrens Hospital, Cleveland, Ohio, USA
  5. 5 Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA
  1. Correspondence to Dr Elie G Abu Jawdeh, Pediatrics, University of Kentucky, Lexington, KY 40506, USA; elieabujawdeh{at}


Intermittent hypoxaemia (IH) events are well described in extremely preterm infants, but the occurrence of IH patterns in more mature preterm infants remains unclear. The objective of this study was to characterise the effect of gestational age on early postnatal patterns of IH in extremely (<28 weeks), very (28–<32 weeks) and moderately (32–<34 weeks) preterm infants. As expected, extremely preterm infants had a significantly higher frequency of IH events of longer durations and greater time with hypoxaemia versus very and moderately preterm infants. In addition, the postnatal decrease in IH duration was comparable in the very and moderately preterm infants. This progression of IH events should assist clinicians and families in managing expectations for resolution of IH events during early postnatal life.

  • neonatology
  • health services research

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  • Contributors JMDF and EGAJ designed and conceptualised the study, oversaw and conducted data collection and analyses at their respective centres and wrote the initial manuscript. VS, TR and RJM designed and conceptualised the study and drafted the article. AP participated in development of the study, oversaw data collection at his centre and drafted the article. AS and SW participated in development of the study plan, performed statistical analyses and drafted the article.

  • Funding The study was funded in part by: (1) The Gerber Foundation, University of Kentucky (EGAJ, PI); (2) University of Kentucky’s National Centre for Advancing Translational Sciences, UL1RR033173; (3) TR is supported by NIH K08HL133459-03 grant; and (4) The Gerber Foundation, Case Western Reserve University (JMDF, co-investigator; Peter MacFarlane, principal investigator).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The institutes’ committees on human research approved the study protocols (Cleveland, Ohio #021814, and Lexington, Kentucky #44278).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request. This study contains data from two university hospital sites. This publication is a retrospective assessment of the two data sets. The data are deidentified. Reuse is not permitted without permission from the authors.