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Absence of relationship between serum cortisol and critical illness in premature infants
  1. Irina Prelipcean1,2,
  2. James Lawrence Wynn2,
  3. Lindsay Thompson2,
  4. David James Burchfield2,
  5. Laurence James-Woodley3,
  6. Philip B Chase3,
  7. Christopher P Barnes3,
  8. Angelina Bernier2
  1. 1 Pediatrics, University of Rochester, Rochester, New York, USA
  2. 2 Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA
  3. 3 Clinical and Translational Science—Informatics and Technology, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Irina Prelipcean, Pediatrics, University of Rochester, Rochester, New York, USA; Irina_Prelipcean{at}


Background Inadequate cortisol production in response to critical illness in extremely preterm infants may exacerbate poor outcomes. Despite commonly measuring cortisol concentration and administering hydrocortisone for presumed adrenal insufficiency, the relationship between serum cortisol concentration and illness severity remains unclear in this unique population.

Objective To determine the relationship between cortisol concentrations and illness severity as measured by the Score for Neonatal Acute Physiology II, neonatal Sequential Organ Failure Assessment and Vasoactive-Inotropic Score in premature infants.

Design/Methods This retrospective, single-center cohort study included preterm infants born <30 weeks gestational age admitted to a level IV neonatal intensive care unit (NICU) between June 2011 and July 2018, who had a serum cortisol obtained for clinical indications before 36 weeks PMA. Demographic data were collected on infants and mothers. Nine clinical variables were identified a priori that could potentially modify cortisol concentration including critical illness. Univariate and multivariable analyses determined the relationship between cortisol concentration and each of these variables.

Results A total of 224 preterm infants with pretreatment serum cortisol concentration met criteria for inclusion. The median (IQR) gestational age at birth was 25 weeks (24, 26) and at cortisol measurement was 26 weeks (25, 28). The median cortisol was 13.3 ug/dL. Non-survivors had the highest values. Cortisol concentration did not correlate with any of the selected illness severity scores.

Conclusion(s) Cortisol concentrations in extremely preterm infants did not correlate with illness severity regardless of gestational age. Further studies are needed to identify clinically useful mediators of adrenal dysfunction and to guide clinical management.

  • neonatology
  • endocrinology

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  • Contributors IRB or collected primary data: IP, LT. Performed the analysis: JLW, LJ-W, PBC, CPB. Wrote first draft: IP. Edited draft: all authors. Concept and content: IP, JLW, AB, DJB, LT.

  • Funding This work was supported by a grant from the Children’s Miracle Network awarded to IP. JLW receives support from the National Institutes of Health (NIH)/National Institute of General Medical Science (R01GM128452) and the NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (R01HD089939, R01HD097081).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval University of Florida Institutional Review Board IRB201800832.

  • Data availability statement Data are available on reasonable request. Data were collected using the University of Florida Health Integrated Data Repository extraction from the electronic medical record in conjunction with chart review. Reuse is not permitted without institutional IRB consent.

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