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Effects of varying chest compression depths on carotid blood flow and blood pressure in asphyxiated piglets
  1. Marlies Bruckner1,
  2. Megan O’Reilly2,3,
  3. Tze-Fun Lee3,
  4. Mattias Neset4,
  5. Po-Yin Cheung2,3,
  6. Georg M Schmölzer1,2,3
  1. 1 Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Steiermark, Austria
  2. 2 Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
  3. 3 Centre of the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, University of Alberta, Edmonton, Alberta, Canada
  4. 4 Faculty of Engineering, University of Alberta, Edmonton, Alberta, Canada
  1. Correspondence to Dr Georg M Schmölzer, Neonatology, University of Alberta, Edmonton T5H 3V9, Alberta, Canada; georg.schmoelzer{at}me.com

Abstract

Background Current neonatal resuscitation guidelines recommend chest compressions (CCs) should be delivered to a depth of approximately 1/3 of the anterior–posterior (AP) chest diameter. The aim of the study was to investigate the haemodynamic effects of different CC depths in a neonatal piglet model.

Methods CCs were performed with an automated CC machine with 33%, 40% and 25% AP chest diameter in all piglets in the same order for a duration of 3 min each.

Results Eight newborn piglets (age 1–3 days, weight 1.7–2.3 kg) were included in the study. Carotid blood flow (CBF) and systolic blood pressure were the highest using a CC depth of 40% AP chest diameter (19.3±7.5 mL/min/kg and 58±32 mm Hg).

Conclusion CC depth influences haemodynamic parameters in asphyxiated newborn piglets during cardiopulmonary resuscitation. The highest CBF and systolic blood pressure were achieved using a CC depth of 40% AP chest diameter.

Trial registration number PCTE0000148.

  • neonatology
  • resuscitation

https://doi.org/10.1136/archdischild-2020-319473

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    Footnotes

    • Contributors Conception and design: GMS, P-YC, MOR and T-FL. Collection and assembly of data: GMS, MOR, T-FL, MN and MB. Analysis and interpretation of the data: GMS, MOR, T-FL, MN and MB Drafting of the article: GMS and MB. Critical revision of the article for important intellectual content: GMS, P-YC, MOR, T-FL, MN and MB. Final approval of the article: GMS, P-YC, MOR, T-FL, MN and MB

    • Funding We would like to thank the public for donating money to our funding agencies: GMS is a recipient of the Heart and Stroke Foundation/University of Alberta Professorship of Neonatal Resuscitation, a National New Investigator of the Heart and Stroke Foundation Canada and an Alberta New Investigator of the Heart and Stroke Foundation Alberta.

    • Competing interests We have developed the automated chest compression machine and have submitted the device for registration of patent.

    • Patient consent for publication Not required.

    • Ethics approval All experiments were approved by the Animal Care and Use Committee (Health Sciences), University of Alberta (AUP00002844), registered at preclincialtrials.eu and conducted according to Animal Research: Reporting of In Vivo Experiments guidelines.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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