Background Current neonatal resuscitation guidelines recommend chest compressions (CCs) should be delivered to a depth of approximately 1/3 of the anterior–posterior (AP) chest diameter. The aim of the study was to investigate the haemodynamic effects of different CC depths in a neonatal piglet model.
Methods CCs were performed with an automated CC machine with 33%, 40% and 25% AP chest diameter in all piglets in the same order for a duration of 3 min each.
Results Eight newborn piglets (age 1–3 days, weight 1.7–2.3 kg) were included in the study. Carotid blood flow (CBF) and systolic blood pressure were the highest using a CC depth of 40% AP chest diameter (19.3±7.5 mL/min/kg and 58±32 mm Hg).
Conclusion CC depth influences haemodynamic parameters in asphyxiated newborn piglets during cardiopulmonary resuscitation. The highest CBF and systolic blood pressure were achieved using a CC depth of 40% AP chest diameter.
Trial registration number PCTE0000148.
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Contributors Conception and design: GMS, P-YC, MOR and T-FL. Collection and assembly of data: GMS, MOR, T-FL, MN and MB. Analysis and interpretation of the data: GMS, MOR, T-FL, MN and MB Drafting of the article: GMS and MB. Critical revision of the article for important intellectual content: GMS, P-YC, MOR, T-FL, MN and MB. Final approval of the article: GMS, P-YC, MOR, T-FL, MN and MB
Funding We would like to thank the public for donating money to our funding agencies: GMS is a recipient of the Heart and Stroke Foundation/University of Alberta Professorship of Neonatal Resuscitation, a National New Investigator of the Heart and Stroke Foundation Canada and an Alberta New Investigator of the Heart and Stroke Foundation Alberta.
Competing interests We have developed the automated chest compression machine and have submitted the device for registration of patent.
Patient consent for publication Not required.
Ethics approval All experiments were approved by the Animal Care and Use Committee (Health Sciences), University of Alberta (AUP00002844), registered at preclincialtrials.eu and conducted according to Animal Research: Reporting of In Vivo Experiments guidelines.
Provenance and peer review Not commissioned; internally peer reviewed.
Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.
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