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Incidence of SARS-CoV-2 vertical transmission: a meta-analysis
  1. Xin Lei Goh1,
  2. Yi Fen Low1,
  3. Cheng Han Ng1,
  4. Zubair Amin2,3,
  5. Yvonne Peng Mei Ng2,3
  1. 1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  2. 2 Neonatology, Khoo Teck-Puat- National University Children's Medical Institute, National University Health System, Singapore
  3. 3 Paediatrics, Khoo Teck Puat-National University Children's Medical Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  1. Correspondence to Dr Yvonne Peng Mei Ng, Neonatology, 1E Kent Ridge Road, NUHS Tower Block Level 12, National University Hospital, Singapore 119228, Singapore; paeynpm{at}nus.edu.sg

https://doi.org/10.1136/archdischild-2020-319791

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    The likelihood of newborns acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from infected mothers has raised concerns among families and clinicians worldwide. Published case reports and case series have individually reported wide variability in rate of vertical transmission. We therefore aimed to determine a more precise risk of vertical transmission, either intrauterine or during delivery, by pooling evidence from current studies.

    We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (CRD42020183500). We searched PubMed, Medline, Embase and China National Knowledge Infrastructure using search terms neonate, pregnancy, COVID-19, 2019-nCoV, SARS-CoV-2 and similar variants until 23 May 2020. Studies reporting mothers who tested positive for SARS-CoV-2 by reverse transcriptase PCR (RT-PCR) and whose newborns were tested by RT-PCR were included. We reviewed 335 full-text articles: 32 studies fulfilled inclusion criteria, 15 overlapping studies were …

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    Footnotes

    • Contributors XLG, YFL: substantial contributions to the acquisition, interpretation of data for the work and revising it critically for important intellectual content. CHN: substantial contributions to the analysis and interpretation of data for the work, and revising it critically for important intellectual content. ZA: substantial contributions to conception and design of the work, analysis and revising it critically for important intellectual content. YPMN: substantial contributions to conception and design of the work, interpretation of data for the work and revising it critically for important intellectual content.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; internally peer reviewed.