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Letter
Reply to: ‘Research on infection prevention bundles: hidden risk of bias?’
  1. Victoria Payne1,2,
  2. Mike Hall2,
  3. Jacqui Prieto1,2,
  4. Mark J Johnson2,3
  1. 1School of Health Sciences, University of Southampton, Southampton, UK
  2. 2University Hospital Southampton NHS Foundation Trust, Southampton, UK
  3. 3NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK
  1. Correspondence to Victoria Payne, School of Health Sciences, University of Southampton, UK; vp1m14{at}soton.ac.uk

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We thank Pieter Degraeuwe for his letter and for highlighting the potential hidden risk of detection bias.1 Our review focused specifically upon reducing central line-associated bloostream infections (CLABSIs) and while we accept that bloodstream infection for all forms of late-onset sepsis is a useful outcome measure, its use would have complicated the interpretation of results relating to reductions in CLABSI. 2

We agree that there are multiple challenges with using CLABSI as an outcome measure, including the variety of …

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