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Physiological effects of high-flow nasal cannula therapy in preterm infants
  1. Zheyi Liew1,2,
  2. Alan C Fenton3,4,
  3. Sundeep Harigopal3,4,
  4. Saikiran Gopalakaje1,2,
  5. Malcolm Brodlie1,2,
  6. Christopher J O’Brien1
  1. 1Paediatric Respiratory Medicine, Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
  2. 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
  3. 3Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
  4. 4Newcastle University, Newcastle upon Tyne, UK
  1. Correspondence to Dr Malcolm Brodlie, Paediatric Respiratory Medicine, Great North Children’s Hospital, Newcastle upon Tyne NE1 4LP, UK; m.j.brodlie{at}ncl.ac.uk

Footnotes

  • MB and CJO’B contributed equally.

  • Contributors ZL and SG: enrolled infants, performed measurements, collected and analysed data. ACF, SH, MB and CJO’B: conceived the study, developed the protocol and study design and analysed the data. All authors had intellectual input to the manuscript and approved the final version as submitted and agree to be accountable for all aspects of the work.

  • Funding Funding from Newcastle upon Tyne Hospitals NHS Charity for equipment. MB was supported by a Medical Research Council Clinician Scientist Fellowship (MR/M008797/1). The research was supported by the National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals NHS Foundation Trust and Newcastle University.

  • Disclaimer The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

  • Competing interests ZL, ACF, SH, SG and CJO’B: none. MB: not related to this work: investigator-led research grants from Pfizer and Roche Diagnostics; speaker fees paid to Newcastle University from Novartis, Roche Diagnostics and TEVA. Travel expenses to educational meeting Boehringer Ingelheim and Vertex Pharmaceuticals.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data available on reasonable request to ORCiD 0000-0003-4591-8299 once study is fully published and analysed subject to approval by full study team.

  • Patient consent for publication Not required.

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Footnotes

  • MB and CJO’B contributed equally.

  • Contributors ZL and SG: enrolled infants, performed measurements, collected and analysed data. ACF, SH, MB and CJO’B: conceived the study, developed the protocol and study design and analysed the data. All authors had intellectual input to the manuscript and approved the final version as submitted and agree to be accountable for all aspects of the work.

  • Funding Funding from Newcastle upon Tyne Hospitals NHS Charity for equipment. MB was supported by a Medical Research Council Clinician Scientist Fellowship (MR/M008797/1). The research was supported by the National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals NHS Foundation Trust and Newcastle University.

  • Disclaimer The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

  • Competing interests ZL, ACF, SH, SG and CJO’B: none. MB: not related to this work: investigator-led research grants from Pfizer and Roche Diagnostics; speaker fees paid to Newcastle University from Novartis, Roche Diagnostics and TEVA. Travel expenses to educational meeting Boehringer Ingelheim and Vertex Pharmaceuticals.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data available on reasonable request to ORCiD 0000-0003-4591-8299 once study is fully published and analysed subject to approval by full study team.

  • Patient consent for publication Not required.

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