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UK survey of less invasive surfactant administration
  1. Eleanor Jeffreys1,2,
  2. Katie Hunt1,2,
  3. Theodore Dassios2,3,
  4. Anne Greenough1,2
  1. 1 Department of Women and Children’s Health, School of Life Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK
  2. 2 MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London, London, UK
  3. 3 Neonatal Intensive Care Unit, King’s College Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Professor Anne Greenough, Department of Women and Children’s Health, School of Life Sciences, Faculty of Life Science and Medicine, King’s College London, London SE5 9RS; anne.greenough{at}kcl.ac.uk

https://doi.org/10.1136/archdischild-2018-316466

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    Increasing use of non-invasive ventilation has led to the development of techniques which deliver surfactant without resort to intubation. These are called less invasive surfactant administration (LISA) or minimally invasive surfactant therapy (MIST). A systematic review of six randomised controlled trials demonstrated LISA use in infants with respiratory distress syndrome was associated with a reduced incidence of bronchopulmonary dysplasia and death at 36 weeks and need for mechanical ventilation1; the latter was also reported in a further systematic review.2 A survey of LISA use across Europe demonstrated variation in practice.3 Only 12 UK units, however, were included hence we determined current practice regarding LISA in all levels of UK neonatal units. An online questionnaire was sent to all …

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    Footnotes

    • Contributors AG, EJ and KH designed the study. EJ and KH undertook the survey, EJ and KH undertook the analysis. EJ wrote the first draft and all authors produced the final manuscript.

    • Funding This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas' NHS Foundation Trust and King’s College London.

    • Disclaimer The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Data sharing statement We are happy to share data on request.

    • Patient consent for publication Not required.

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