Article Text

other Versions

Download PDFPDF
Highlights from the literature

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Alcohol and the fetus

We all know about fetal alcohol syndrome, though we don't see it a lot even in populations with legendary high alcohol intakes. But until Muggli et al reported their findings this year (JAMA Pediatr. doi:10.1001/jamapediatrics.2017.0778), we had no idea that there was a dose dependent and persistent effect of maternal alcohol consumption on the craniofacial morphology of exposed babies. Importantly, this was not visible to the clinical eye but emerged when 3-dimensional images were captured in infants who were a year old. Because information on alcohol intake in pregnancy was gathered prospectively, and only the 415 children (326 of which were exposed to alcohol prenatally) with complete information on co-variates were included in the analysis, these data are about as robust as you can get in a cohort study. Unsurprisingly alcohol impacted on craniofacial development maximally in the first trimester, but the nature of intake (for example, binge drinking) seemed to make a difference too.

The ART of Beckwith-Wiedemann syndrome

Continuing the theme of embryopathy, Mussa et al (Pediatrics. 2017;140(1):e20164311) used a population based congenital anomaly register in Italy (Piemonte) to examine the impact of artificial reproductive technologies (ART) on the birth prevalence of Beckwith-Wiedemann syndrome. …

View Full Text


  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.