Article Text

other Versions

Download PDFPDF
No Change in Developmental Outcome with Incubator Covers and Nesting for Very Preterm Infants in a Randomized Controlled Trial
  1. Celeste M. Maguire (c.m.maguire{at}
  1. Leiden University Medical Center
    1. Frans J. Walther (f.j.walther{at}
    1. Leiden University Medical Center
      1. Paul H.T. van Zwieten (p.vanzwieten{at}
      1. Haga Hospital, location Juliana Children's Hospital
        1. Saskia Le Cessie (s.le_cessie{at}
        1. Leiden University Medical Center
          1. Jan M. Wit (j.m.wit{at}
          1. Leiden University Medical Center
            1. Sylvia Veen (s.veen{at}
            1. Leiden University Medical Center


              Objective: Randomized controlled trial investigating effect of basic elements of developmental care (DC) (incubator covers and positioning aids) on growth and neurodevelopment in infants born <32 weeks.

              Method: Infants were randomized within 48 hours of birth to DC group or standard care (C) group. Outcome measures at 1 and 2 years corrected age (CA) were growth, standardized neurological exams and mental (MDI) and psychomotor (PDI) development (Dutch version of the Bayley Scales of Infant Development II).

              Results: 192 infants were recruited (DC=98; C=94). Thirteen infants (DC=7, C=6) were excluded because they were admitted less than or died within the first 5 days. In total, 179 infants met inclusion criteria. In-hospital mortality was 12/91 (13.2%) in DC group and 8/88 (9.1%) in C group. 147 children (DC= 74, C= 73) at 1 year and 142 children (DC=72, C=70) at 2 years were assessed. No significant difference in growth, neurological outcomes or MDI was found. A positive trend in PDI at 1 year (p=0.05) did not continue once the children reached 2 years. There was no difference found when neurological and developmental scores were combined.

              Conclusions: Basic developmental care has no positive effect on neurological and mental development or growth at 1 and 2 years in infants born < 32 weeks. A positive effect on psychomotor development at 1 year did not continue at 2 years of age.

              Statistics from

              Request Permissions

              If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

              Linked Articles

              • Fantoms
                Martin Ward Platt