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Systemic antifungal prophylaxis for very-low-birth-weight infants: systematic review
  1. Linda Clerihew
  1. Wishaw Hospital, United Kingdom
    1. Nicola Austin
    1. Christchurch Women's Hospital, New Zealand
      1. William McGuire (william.mcguire{at}
      1. Australian National University, Australia


        Systematic review and meta-analysis of four randomised controlled trials suggests that prophylactic fluconazole reduces the incidence of invasive fungal infection in very-low-birth-weight infants. Further trials are needed to provide more precise estimates of effect size, and to assess the effect on mortality, neurodevelopment, and the emergence of antifungal resistance.

        • antifungal prophylaxis
        • very-low-birth-weight

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