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- Published on: 5 June 2006
- Published on: 3 April 2006
- Published on: 20 July 2005
- Published on: 5 June 2006Gentamicin and Amikacin: extended interval dosing in neonates.Show More
Dear Editor,
Recently it has been published a meta-analysis of Cochrane which, specifically for gentamicin, compares daily dose versus multiple dose scheme, and it concludes that, although daily dose could be better, the evidence is even insufficient to confirm it. (1) Additionally, paper of Nestaas included gentamicin and amikacin, although it had got only two papers with amikacin in its references, in accordin...
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None declared. - Published on: 3 April 2006Aminoglycoside extended interval dosing in neonates is safe and effective.Show More
Dear Editor,
The meta-analysis “Aminoglycoside extended interval dosing in neonates is safe and effective: a meta-analysis”[1], has been commented on by Emmerson and Edi-Osagie[2] and by Lounghnan[3]. In the meta-analysis, extended interval dosing (EID) were found to provide fewer unfavourable serum drug concentrations (SDC) than traditional dosing (TD), treatment failure to be rare (2 failure were reported in...
Conflict of Interest:
None declared. - Published on: 20 July 2005Single daily dose aminoglycosides in the neonatal period appear to be effective: but are they safe?Show More
Dear Editor,
A recent article by Nestaas et al.[1] deserves comment. This meta- analysis attempts to evaluate the relative efficacy and toxicity of “extended interval dosing” (EID), compared to “traditional dosing” (TD), of aminoglycosides administered to newborn infants. The conclusion of the analysis was that “extended interval dosing of aminoglycosides in neonates is safe and effective, with a reduced risk of se...
Conflict of Interest:
None declared.