Article Text

Download PDFPDF
PPO.30 Assessment of adverse perinatal outcomes in women with isolated PAPP-A <0.3 at firt trimester screening
  1. K Skorupskaite,
  2. L Stirrat,
  3. N Palaniappan,
  4. C Shearing,
  5. S Cowan
  1. Simpsons Centre for Reproductive Health, New Royal Infirmary of Edinburgh, Edinburgh, UK


Background Maternal serum pregnancy-associated-plasma-protein-A (PAPP-A) was introduced as a part of combined first trimester trisomy 21 screening (nuchal translucency, PAPP-A and human chorionic gonadotropin) in 2011. We aimed to investigate whether isolated low PAPP-A (< 0.3MoM) was associated with stillbirth, preterm delivery and low birthweight in women booked for delivery in NHS Lothian in 2011.

Methods We retrospectively reviewed case records of women with low PAPP-A level during 2011 (n = 154). Rate of stillbirth, preterm delivery and low birthweight were compared with a control group (n = 9603) who had a normal PAPP-A result, or had opted out of screening. Chi-squared test was used for comparison of rates. Statistical significance was considered at p < 0.05.

Results Rates of stillbirth, preterm delivery and low birthweight were significantly higher in women with low PAPP-A (Table 1).

Abstract PPO.30 Table 1

Conclusions Our results suggest that low PAPP-A at first trimester screening is associated with significantly higher rates of stillbirth, preterm delivery and low birthweight.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.