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Despite the high prevalence of infantile haemangioma (IH) of preterm infants, methods for treating it have not yet been evaluated in controlled trials.1 Therefore, we conducted a prospective controlled study, comparing nitrogen-cooled cryocontact therapy (NCCT,−196°C) for early treatment of IH in preterm infants with no treatment.
From 1 August 2004 to 31 December 2008, we allocated IH of infants ≤34 weeks gestational age with at least two IH into either a cryocontact or a control group, thus using intraindividual controls to exclude interpersonal differences potentially affecting growth. If IH appeared simultaneously, they were numbered from head to foot; even numbers were treated, odd numbers served as controls. In sequentially erupting IH, always the second one …
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics Committee of Tuebingen University Hospital.
Provenance and peer review Not commissioned; externally peer reviewed.