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Prospective controlled study to evaluate cryocontact therapy for infantile haemangioma in preterm infants
  1. Rangmar Goelz1,
  2. Monika Moll1,
  3. Christoph Meisner2,
  4. Martin Röcken3,
  5. Christian F Poets1,
  6. Matthias C Moehrle3
  1. 1 Department of Neonatology, University Childrens's Hospital, Tuebingen, Germany
  2. 2 Institute of Medical Biometry, Tuebingen, Germany
  3. 3 University Hospital of Dermatology, Tuebingen, Germany
  1. Correspondence to Dr Rangmar Goelz, Department of of Neonatology, University Childrens Hospital, Calwerstrasse 7, Tuebingen D-72076, Germany; Rangmar.Goelz{at}

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Despite the high prevalence of infantile haemangioma (IH) of preterm infants, methods for treating it have not yet been evaluated in controlled trials.1 Therefore, we conducted a prospective controlled study, comparing nitrogen-cooled cryocontact therapy (NCCT,−196°C) for early treatment of IH in preterm infants with no treatment.

From 1 August 2004 to 31 December 2008, we allocated IH of infants ≤34 weeks gestational age with at least two IH into either a cryocontact or a control group, thus using intraindividual controls to exclude interpersonal differences potentially affecting growth. If IH appeared simultaneously, they were numbered from head to foot; even numbers were treated, odd numbers served as controls. In sequentially erupting IH, always the second one …

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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics Committee of Tuebingen University Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.