Introduction A variety of other pregnancy outcomes other than neural tube defects and aneuploidy have been associated with abnormal values of different analytes used in second trimester screening tests.

Aim To review the obstetrical outcomes associated with abnormally elevated or decreased level of maternal serum marker analytes used in second trimester screening for aneuploidy.

To provide guidance to facilitate the management of these pregnancies and to assess the usefulness of these markers as a screening test.

Method and Setting Retrospective analysis of 102 case notes with high risk screening result just over a period of two years from January 2007 – May 2009 at Manor Hospital, Walsall.

Results 102 patients were included in the study. 77% of the patients had high risk results for Down’s syndrome out of which 67% of them accepted amniocentesis. Chromosomal abnormality was identified only in three fetus.

24 women had high risk results for neural tube defects and 3 women had fetus with CNS abonormality.

70% of the women had normal outcome. Less than 1/3 rd of the women developed complication like pre-eclampsia, placental problems like low lying placenta, adherent placenta, abruption etc and difficulties in induction of labour.

45% of fetus had abnormal outcome. Majority (45%) were small for gestation less than 10^th centile followed by preterm delivery and macrosomia.

Conclusion Down’s screening analytes have low predictive accuracy but may be useful means of risk assessment or of use when combined with other maternal factors.