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Fetal Medicine Posters
PF.62 Computational Reconstruction of Human Fetal Cardiac Ventricular Wall Development
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  1. E Pervolaraki1,
  2. R Anderson2,
  3. M Paley3,
  4. AV Holden1
  1. 1Faculty of Biological Sciences, University of Leeds, Leeds, UK
  2. 2MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK
  3. 3Academic Radiology, University of Sheffield, Sheffield, UK

Abstract

We construct a computational model of the electrophysiology of the developing heart.

Anisotropic geometry at ∼100 µm voxel resolution was obtained from Diffusion Tensor and Fast Low Angle Shot Magnetic Resonance Imaging and electrical activity from fetal electrocardiograms obtained longitudinally from one gestation and from multiple studies.

Transmural myofibre organisation is established by 136 days gestational age (DGA) and during 2nd and 3rd trimester QR intervals decrease by 20 ms while heart dimensions increase by a 2-fold. This implies an increase in the ventricular conduction velocity. A computational model of the 140 DGA human ventricle is presented that combines cell electrophysiology with anisotropic geometry.

https://doi.org/10.1136/archdischild-2013-303966.071

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