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The prevalence of overweight and obesity in women of childbearing age is up to 60% in developed nations.1 We sought to determine whether maternal adiposity is associated with aortic wall thickening in newborns, prior to prolonged postnatal exposure to potential confounders; and if so, whether this association is independent of birth weight, a known risk factor for later cardiovascular disease.
Twenty-three pregnant women, age 35.6 years (SD 4.8; range 27.0–44.6), were recruited at 16.3 weeks gestation (SD 2.2; range 11.4–20.6) from The Women's Hospital, Melbourne, Australia. Women who had quit smoking in the previous 6 months were excluded; however those who continued to smoke were not. Maternal height and weight were measured at study entry. Overweight and obesity was defined as a body mass index (BMI)≥25 kg/m2, which we believe will not …
Contributors LMB, RP-D, JW, JPFC-D and MRS designed and conducted the study. MRS wrote the statistical analysis plan, analysed the data and drafted the manuscript. All authors contributed to data interpretation and revision of the manuscript. MRS is guarantor.
Funding Financial support for the submitted work from the Foundation for Children (#2009-161). MRS received support from NHMRC fellowships (#418598, #1004474). Funding bodies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, and approval of the manuscript.
Competing interests None.
Ethics approval RWH Human Research Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.