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Intrapartum antibiotic prophylaxis for prevention of group B streptococcal disease in preterm infants
  1. Joanne Hegarty1,
  2. Abdul Qader Tahir Ismail2,
  3. Christos Ioannou3,
  4. Louise Anthony1,
  5. Lawrence Impey3,
  6. Mark Anthony1
  1. 1Neonatal Unit, John Radcliffe Hospital, Oxford, UK
  2. 2Department of Paediatrics, Good Hope Hospital, Birmingham, UK
  3. 3Department of Obstetrics, John Radcliffe Hospital, Oxford, UK
  1. Correspondence to Dr Abdul Qader Tahir Ismail, Department of Paediatrics, Good Hope Hospital, Rectory Road, Sutton Coldfield, Birmingham B75 7RR, UK; aqt.ismail{at}

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Vergnano et al 1 showed that of 48 infants with early-onset group B streptococcal (GBS) sepsis, 32 mothers had risk factors for neonatal infection, but only 6 mothers were given adequate intrapartum antibiotic prophylaxis (IAP). However, neonatal audit as a tool to define the adequacy of IAP administrations inherently biased simply because infants with GBS sepsis are likely to be born to mothers who have not received IAP. To define the effectiveness of IAP administration, we audited the notes of 102 women with risk factors for early-onset sepsis in 2011.

The results are as follows:

  • Twenty-seven notes of women who had prelabour rupture of membrane (PROM; …

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  • Contributors All authors listed were involved in analysing patient notes, background literature search, analysis of results and writing of the manuscript.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed