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The most commonly used drugs for closure of a haemodynamically significant patent ductus arteriosus (hsPDA) are cyclooxygenase inhibitors, mainly indomethacin and intravenous/oral ibuprofen. In contrast to high closure rates, several adverse effects have been reported with such medications, including gastrointestinal bleeding and perforation, weakened platelet aggregation, hyperbilirubinaemia and renal failure.1 ,2 The role of paracetamol as an …
Competing interests None.
Patient Consent Obtained.
Ethics approval Zekai Tahir Burak Local Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.