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The impact of oral sucrose on apnea and bradycardia in preterm infants: a randomised cross-over trial
  1. Tanja Karen1,
  2. Scarlet Vatlach1,
  3. Anette Poets1,
  4. Christoph Maas1,
  5. Christian F Poets1,
  6. Dirk Bassler1,2
  1. 1Department of Neonatology, Tuebingen University Hospital, Tuebingen, Germany
  2. 2Center for Pediatric Clinical Studies, Tuebingen University Hospital, Tuebingen, Germany
  1. Correspondence to Dirk Bassler, Tuebingen University Hospital, Department of Neonatology, Tuebingen 72076, Germany; Dirk.Bassler{at}

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Pain may promote apnea of prematurity (AOP).1 Oral sucrose is effective for analgesia2 but no study has investigated its effect on the prevention of AOP.

Our ethics committee approved the study and we obtained informed consent. Patient inclusion criteria were: gestational age < 32 weeks, chronological age at study entry ≥ 10 days and postmenstrual age < 36 weeks, caffeine and nasal continuous positive airway pressure (CPAP); need for additional oxygen < 30%, median apnea score ≥ 5 per …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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