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Barzilay et al1 stated recently that oral ibuprofen is more effective than intravenous ibuprofen for patent ductus arteriosus (PDA) closure. They attribute this superiority to pharmacokinetics; maintaining therapeutic plasma levels over a longer time extending the drug's therapeutic effect.
In an attempt to support their conclusion, they compare ibuprofen area under the curve (AUC) 0→24 generated by their study with data …
Competing interests None.
Provenance and peer review Not commissioned; internally peer reviewed.
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