Background There is little evidence for modifiable factors for normal pregnancy. Most work has focused on prediction of complicated pregnancy.
Methods Data from 3513 healthy nulliparous women with a singleton pregnancy participating in the SCreening fOr Pregnancy Endpoints study from six centers in New Zealand (Auckland), Australia (Adelaide), UK (London, Manchester, Leeds) and Ireland (Cork) were analysed using logistic regression to identify risk and protective factors for uncomplicated pregnancy in nulliparous women.
Main outcome measure Uncomplicated normotensive pregnancy, delivered at >37 weeks, with a liveborn baby not SGA, excluding pregnancies with significant other complication.
Results Of the 3513 women, 1973 (56%) had an uncomplicated pregnancy and 1540 (44%) had a complicated pregnancy. Potentially modifiable factors were identified (table 1).
Non-modifiable risk factors included participant's birthweight, Indian ethnicity, hypertension on oral contraception, asthma, family history of pregnancy hypertension, paternal history of heart disease, two vaginal bleeds in current pregnancy, gastroenteritis, uterine artery resistance index and femur length.
Conclusions These results provide firm evidence on which to base recommendations for pre- and early pregnancy counselling to improve the likelihood of having a normal uncomplicated pregnancy.
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Funding Health Research Council, New Zealand; Tommy's, UK.