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Does pulmonary function change during whole-body deep hypothermia?
  1. Giacomo Cavallaro1,
  2. Luca Filippi2,
  3. Gloria Cristofori1,
  4. Mariarosa Colnaghi1,
  5. Luca Ramenghi1,
  6. Elisa Agazzani3,
  7. Andrea Ronchi1,
  8. Patrizio Fiorini2,
  9. Fabio Mosca1
  1. 1Neonatal Intensive Care Unit, Fondazione IRCCS Cà Granda–Ospedale Maggiore Policlinico, University Department of Mother and Infant Sciences, University of Milan, Milan, Italy
  2. 2Neonatal Intensive Care Unit, Department of Critical Care Medicine, “A. Meyer” University Children's Hospital, Florence, Italy
  3. 3Neonatal Intensive Care Unit, “Carlo Poma” Hospital, Mantova, Italy
  1. Correspondence to Dr Giacomo Cavallaro, Neonatal Intensive Care Unit, Fondazione IRCCS Cà' Granda–Ospedale Maggiore Policlinico, University Department of Mother and Infant Sciences, University of Milan, Via Della Commenda 12, 20122 Milan, Italy; giacomo.cavallaro{at}mangiagalli.it

Abstract

Whole-body deep hypothermia (DH) could be a new therapeutic strategy for asphyxiated newborn. Aim of this study was to describe how DH (core temperature 30–33°C) modifies the respiratory function if compared with mild hypothermia (MH; core temperature 33–34°C). This is an observational study. Results were obtained from a pilot study of safety of DH and topiramate in neonatal hypoxic-ischaemic encephalopathy. Fifty-seven newborns were enrolled: 29 patients in DH and 28 in MH. Recruitment criteria were moderate-severe hypoxic-ischaemic encephalopathy and gestational age ≥36 weeks. Mechanical ventilation was set to maintain SaO2 between 92% and 95%. Nineteen patients in DH and 18 in MH required mechanical ventilation. Of these patients, 10 and 12, respectively, did not required oxygen. No significant differences were observed in hours of oxygen and ventilation support, respiratory rate and PaCO2. Maximum FiO2, peak inspiratory pressure, positive end-expiratory pressure, minute ventilation and tidal volume during hypothermia were similar. Pulmonary function with different levels of hypothermia was similar.

https://doi.org/10.1136/adc.2009.181826

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    Footnotes

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval The study protocol was approved by the Medical Ethical Committee of the “Carlo Poma” Hospital, Mantova and the “A. Meyer” University Children's Hospital, Florence, Italy.

    • Provenance and peer review Not commissioned; externally peer reviewed.