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We read the article by Jones et al with great interest describing
Ibuprofen may increase the risk of chronic lung disease (CLD) compared to
Indomethacin. We are unsure whether the data presented is fully supportive
of the conclusion that Ibuprofen poses a greater risk of CLD compared to
Indomethacin and whether this is clinically significant.
In Figure 4 the pooled risk ratio (RR) was 1.28 (95...
In Figure 4 the pooled risk ratio (RR) was 1.28 (95% confidence
interval (95%CI) 1.03-1.60) and the p value p=0.03. However only 6 studies
were used, of these only 3 showed a higher risk ratio with Ibuprofen, with
the other 3 studies in fact showing a protective effect. The lower end of
the pooled RR 95% CI was also somewhat close to 1.0. In addition all the
studies' 95% confidence intervals of the RR include 1.0, further reducing
the statistical significance despite the p value being significant.